Too many patients, as documented in an on-line study of 12,000 individuals conducted by the American Thyroid Association published in June 2018, (https://doi.org/10.1089/thy.2017.0681) , complain of persistent symptoms of hypothyroidism despite what their doctors believe is successful treatment with levothyroxine (brands include Synthroid, Unithroid, Tirosent, Levoxl). We believe something needs to be done to resolve this conflict between patients and their doctors.
Suzi has hypothyroidism and high blood pressure. She sends the following story describing how t3 treatment appeared to help normalize her blood pressure. This is the first time I have come across this effect and thought it would be helpful to share her story on the main blog. Does anyone else have a similar (or contradictory) experience?
Hi Dr. Pepper,
I was diagnosed hypothyroid 2 years ago and given levothyroxine. On diagnosis I had lots of symptoms and my BP was 175/115 despite my whole family having low BP. After some months on T4 I did feel an improvement in a lot of ways and my BP got better. Then after a year, things started going wrong, as if my body didnâ€™t like T4.
I tried reducing my dose of T4 back down to 75Âµg but went hypo. But each time I increased above 75Âµg my BP increased again, then on 112Âµg it became a serious problem, especially the diastolic. I still had fatigue, constipation, red eyes, swollen legs and so on.
About 3 weeks ago I started on 10Âµg T3 and reduced my T4 from 112 to 75Âµg and pretty much immediately felt clearer headed and more energy, the constipation went etcâ€¦.. My BP has gone down by an average of 20, which I know because I check it regularly myself. Iâ€™m doing a 24-hour BP monitor this week too, because my doctor put me on Amlopidine 6 weeks ago after being shocked by the monitor results from then while on 112Âµg T4 (only took Amlopidine for 2 weeks after terrible side-effects incl. overwhelming fatigue and massively swollen legs).
So, it looks as though my body goes weird on T4 tablets when the dose is above 75Âµg, but if I stuck to that dose Iâ€™d be really hypothyroid. The T3 has changed my life completely!!
Now Iâ€™m wondering what the ideal balance T4 / T3 tablets would be? Is that possible to say or does it depend on each individual body and genetics? My typical BP now is around 120/ 95; it goes down after eating, and gets worse when Iâ€™m hungry or tired. The T3 reduced my BP so much more than the Amlopidine did, and on T3 I feel great whereas on Amlopidine I felt half dead. Iâ€™d like to get my BP back to before I got hypo, so thatâ€™d be 110/70.
All I need to do now is find my ideal dose of T4 and T3, could you possibly advise me on that? If I started 20Âµg T3 instead of 10Âµg, would you advise a reduction in T4 from 75Âµg? ( Iâ€™ll be doing a TSH, fT3 and fT4 test in about 5 weeksâ€™ time, maybe I should wait till then?).
Thank you so much!