I just returned from a conference on the latest wonder drug to be launched in the battle against diabetes Type 2 diabetes (the kind treated with pills, not insulin injections). The drug, brand named Byetta,(exenatide), is a derivative of a compound in the saliva of the Gila Monster. These ugly and venomous lizards eat 3 times per year. How about that for metabolism? Helping them accomplish that is a chemical in their digestive tract that turns insulin production on when needed. The scientific name of this naturally occurring substance is glucagon-like-peptide 1, or GLP-1, for short. Since diabetics don’t make enough insulin this wonder drug is ideal for helping them get more of what they need.
As if that isn’t enough, Byetta (the synthetic version of the compound in Gila Monster spit) turns off feelings of hunger. What is the result in humans? You guessed it,… weight loss. Not just routine weight loss but a weight loss that keeps on going and going and going. In one preliminary study the weight loss continued for up to 82 weeks.
Is there a downside to all this? Certainly. First of all, the medicine must be self administered as an injection twice a day. Second, some people experience nausea or constipation using Byetta. The degree of unpleasant gastro-intestinal symptoms produced by this novel medicine will likely determine how wide spread its use will be. One wonders if it could become the next blockbuster drug.
Byetta is marketed by Amylin Pharmaceuticals and Eli Lilly Company and is available by prescription only. If you suffer from Type 2 diabetes you may want to ask your doctor if artificial lizard spit is right for you.
The mission of the The Thyroid Project is to encourage sharing of information and experience between the public and the medical community about the treatment of hypothyroidism (low thyroid function). For at least the past few decades there is a growing awareness of â€œsomething missingâ€ in the way suffers of hypothyroidism are treated for their disease.
Too many patients, as documented in an on-line study of 12,000 individuals conducted by the American Thyroid Association published in June 2018, (https://doi.org/10.1089/thy.2017.0681) , complain of persistent symptoms of hypothyroidism despite what their doctors believe is successful treatment with levothyroxine (brands include Synthroid, Unithroid, Tirosent, Levoxl). We believe something needs to be done to resolve this conflict between patients and their doctors.
Discover the impact of AI on the spread of medical information! Dr. Gary M. Pepper examines the risks of relying on AI summaries from potentially tainted sources, highlighting a controversial NEJM study on testosterone treatment. Learn why it’s crucial to keep public medical data clean and what this means for the future of health information.
Metformin has been the mainstay of diabetes treatment for 50 years with an impressive array of success stories in terms of effectiveness and affordability. On top of this, recent research points to the unexpected potential of metformin for the ability to reduce the risk of dementia and cancer and may even slow the aging process. So why is this drug so under-rated? Our review at metabolism.com digs into these intriguing questions.
Without effective intervention the early stage of type 2 diabetes known as prediabetes carries a high risk of progressing to outright diabetes. Metabolism.com provides an up-to-date summary of recommendations from national authorities, for preventing and possibly reversing this life long affliction