Author Archives: Dr. G. Pepper

About Dr. G. Pepper

Board Certified by the American Boards of Internal Medicine, and Endocrinology and Metabolism Dr. Pepper received his medical degree from the Tufts School of Medicine in Boston. He completed his internship and residency in internal medicine at Montefiore-Einstein Medical Center in New York. In addition, Dr. Pepper completed fellowship training in Endocrinology and Metabolism at Mt. Sinai Medical Center in New York City. From 1989 to 1994 Dr. Pepper served as Chief of the Division of Endocrinology and Metabolism at Lincoln Medical Center in the Bronx. From 1994 to 1996, he was Associate Chief of Medicine at Brooklyn Hospital Center, director of the hospital’s Diabetes Treatment Center, and Clinical Associate Professor of Medicine at New York University School of Medicine. Dr. Pepper has published numerous articles in distinguished journals such as Archives of Internal Medicine, American Journal of Medicine, Fertility and Sterility, the New England Journal of Medicine and co-authored a textbook chapter on the relationship between hormones and psychiatric illness. In recognition of these accomplishments Dr. Pepper was selected as one of the top 100 physicians in New York City by New York Magazine. He is also a featured expert with CNBC and ivillage on topics of diabetes and endocrinology. Dr. Pepper joined Palm Beach Diabetes and Endocrine Specialists in 1996. Of the practice of medicine he says, Almost daily I reread the words of Sir William Osler: "It’s often more important to know what sort of person this disease has than to know what disease the person has."

Patti Keeps on Running Despite Thyroid Cancer


Thyroid cancer is one of the most common cancers of young adults. Many of these cancers have no symptoms until a routine exam reveals a lump in the neck. This was the case with Patti who shares her upbeat experience with us. The good news about this type of cancer is that despite spread to lymph nodes (metastasized) it is still very curable. So, if you notice an unexplained neck lump don’t hesitate to have it evaluated by an endocrinologist or other knowledgeable physician.

Here is what Patti has to say about her thyroid cancer experience;

I found a lump in my throat in August of this year. I am one of the few (about 10%) who tested positive for Thyroid cancer. I also had cancer in 4 of the lymph nodes of my neck. I am a competitive athlete (for fun not for a living) and I worried what would happen. I had surgery in September and although the last 4 months have been very hard on me, I am happy to report I am running, swimming and cycling again. The cancer is completely gone based on my body scan and negative bloodwork.

Most likely you do NOT have cancer. But you can’t roll the dice and not know. And if you do, you can and will get through it and go on to live a wonderful life. It takes work and perseverance to be healthy but it is worth it. 🙂

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Margie Reports Her Success with Armour Thyroid


Hello, Everyone

I was diagnosed Hypothyroid 10 years ago, I have two sisters and several aunts with the same problem. I was prescribed synthroid and it was a Godsend for the first three years even though I was up and down, however I began to be more and more tired and just generally did not feel good, my dosage was up and down, finally doctor prescribed cytomel to go with it. still no good my bones hurt all the time especially my hip going down my leg and in the middle of my upper back, my beautiful teeth damaged. I finally told my Doctor to either give me the Armour or I was going to find another Doctor who would, He did and shazamm all symptoms disappeared, I feel great Like before I ever had this problem, I Thank God for Armour, and I also avoid flouride, chlorine

Find Out What’s New for Treatment of Hot Flashes


With menopause comes the onset of hot flashes. These are the result of the drop in estrogen in the blood. Replacing estrogen is the most effective way of eliminating hot flashes but because of the health risks, taking estrogen replacement is an unacceptable option for many women. A recent study in the Journal of Clinical Oncology reports on the use of other prescription drugs that can alleviate hot flashes. Watch my video on the subject for a more in depth discussion.

HCG is a Hairy Hormone



By Gary Pepper, M.D.
Editor, Metabolism.com
In the first article in this series, The HCG-Cancer Connection, I explained how HCG is made by some types of cancer and can serve as a marker for cancer activity. Now I want to explore another effect of HCG, the stimulation of male hormone (testosterone) production.
Just to review, there is no evidence that HCG will cause cancer although conceivably certain cancer responsive tumors may grow faster due to its effect to increase estrogen and testosterone. Every woman who has had a normal pregnancy has been exposed to high HCG levels for many months so if it did cause cancer that effect would be very obvious.
What concerns me is how HCG can influence the normal ovary and its hormone metabolism. HCG is a promiscuous hormone. It will hook up with different hormone “receptors” and masquerade as these other hormones. In the previous article I explained how at very high levels HCG can stimulate the thyroid to make thyroid hormone resulting in hyperthyroidism. Another hormone effect of HCG is to mimic LH (leutinizing hormone) which turns on the production of the sex hormones by the testicle in men and ovary in woman. Surprisingly the normal ovary makes testosterone which it then converts to estrogen. FSH (follicle stimulating hormone) from the pituitary helps the ovary change testosterone to estrogen. What happens when the ovary gets a lot of LH but not FSH? This is the situation when a woman gets HCG. Testosterone levels will rise more than estrogen levels. Research shows that after a single HCG injection a rise of 20% in testosterone levels occurs in normal women, confirming this theory. During pregnancy with HCG pumping in the blood from the placenta, testosterone levels can double, resulting in acne, oily skin and (in some women) an increase in sex drive. The situation would be far worse for a pregnant woman if the placenta wasn’t also pumping out 100 times the normal amount of estrogen to counteract all the male hormones.
So why should women care if HCG makes their testosterone levels go up? Acne, oily skin and horniness are one thing but there are other effects which might be less acceptable. Testosterone is a mischievous hormone. While it causes hair growth where you don’t want it, it causes hair loss in places you want to keep it. Testosterone stimulates hair growth on the face, chest, back and abdomen. At the same time it causes hair loss from the scalp particularly at the temples and crown. This is referred to as male pattern baldness. Other effects of testosterone in women are the growth of the clitoris, known as clitoromegaly. A clitoris the size of a man’s thumb has been described in a woman due to excess testosterone exposure. Generally this degree of clitoromegaly is seen only in more extreme cases. So you may want to think twice before starting an HCG diet unless looking like Bruce Willis is your thing.
In the final installment on the hazards of HCG I will focus on other possible nasty hormone effects of HCG such as fibroids, infertility and bulging muscles.

Lovey Needs Encouragement to Deal with Her Condition


Sad LadyLovey posts this sad message to metabolism.com. Many of the members here have been through this type of paralyzing doubt and have found a way to get the help they need. So, if you have a minute to spare, in the spirit of the season, why not offer Lovey a message that will help her get her nerve up to go to the doctor.

Lovey writes:

Hi, I’m too scared to go to the doc as I have a large lump in my throat. I don’t know much about thyroids or how it works an wat the worse case situations r. Alls I know is that the lump is about as round n size of a golf ball maybe abit smaller. I’ve had this lump for about 4 years an it’s recently started to get bigger. Ive gain about 12kg in about 8 months but I still do everything the same. I weigh 75 kg an MT height is 174cm. Something is wrong isn’t it!!!

Here is my reply to her;

Hi Lovey

A sluggish thyroid often produces a “lump” in the neck (which is the enlarged thyroid) and weight gain due to a slow metabolism. I’m not sure if you believe me but there really isn’t anything to be scared about. For example, if it turns out your thyroid is under active (low functioning or hypothyroid) the treatment is very simple. For most people taking one pill per day is all that is required to get back to normal. May people with hypothyroid are taking their thyroid pill and feel fine.

It’s hard to say exactly what the problem is in your case, but I wouldn’t be surprised if it is something like hypothyroidism, which could be fixed so easily.

So please get yourself to a doctor, clinic or whatever and have them look into this. Then you can stop worrying so much.

Okay? Let us know what happens. I’m asking other members here to give you their words of support as well, since many of the members here have gone through what you are experiencing and are happy they received proper treatment.

Dr. G. Pepper

HCG, Your Hormone Metabolism and Cancer


by Gary Pepper, M.D.
Editor, Metabolism.com

Last week Helen, a friend of the family, called to brag she had lost 12 pounds in 4 weeks and also to ask if she had given herself cancer in the process. What was the connection between her supposed miracle metabolism and cancer? Helen was taking HCG injections and just read this hormone was somehow related to cancer. I reassured her that I didn’t think she was giving herself cancer by taking HCG but I did let her know that very soon she was likely to resume her normal metabolism and regain the weight she lost. Unfortunately her wallet was never going to recover what it lost in this process. Many services prescribing HCG treatment for weight loss are charging $400 or more for a course of treatment.

Now what about the cancer-HCG connection?

HCG is a hormone normally produced by the fertilized egg in the earliest stages of fetal development and then later by the placenta itself. Since rising HCG level is one of the earliest hormone changes during pregnancy, measuring this hormone is the basis for the everyday pregnancy test. HCG also causes the ovary to make progesterone which is essential for preparing the uterus to become a nesting ground for the developing embryo. HCG may also suppress immune function so that the fetus is not rejected by the mother’s immune system.

The placenta forms at the onset of pregnancy to support the developing embryo and later the fetus. If a sperm fertilizes an empty egg at the onset of pregnancy a Hyditidiform mole can arise in conjunction with or instead of the normal placenta. This is also referred to as a molar pregnancy. HCG levels can rise to extreme levels in the presence of the Hyditidiform mole particularly if it goes on to become an invasive cancer known as a choriocarcinoma. Body chemistry gets a little weird at this stage. HCG is slightly similar in structure to TSH, the pituitary hormone that stimulates the thyroid. The result is that when HCG levels are extremely high as with a molar pregnancy, the thyroid can be stimulated to make excess thyroid hormone resulting in hyperthyroidism in the mother. Typical symptoms of hyperthyroidism can occur including feeling hot, shaky, sweatiness, palpitations, vomiting (which can be severe) and diarrhea. Curing the cancer will cure the hyperthyroidism as well.

Other cancers of the reproductive system can make HCG as well. Certain testicular cancers can make HCG. Since HCG is the hormone responsible for a positive pregnancy test, testicular cancer can sometimes be diagnosed in men by a positive pregnancy test. For tumors making HCG, measuring levels of this hormone during cancer treatment can aid doctors in determining whether therapy is working or not.
Certain cancers are termed “hormone responsive”. That means the cancer will grow more aggressively in the presence of a particular hormone. Tumors that grow faster in the presence of estrogen include receptor positive breast cancer and endometrial cancer. A tumor that grows faster in the presence of testosterone is prostate cancer. Since HCG is likely to increase these hormones, it is conceivable that should a hormone responsive tumor already exist in the body it could grow faster during HCG treatment.

So Helen, I don’t think HCG is going to give you cancer, but it may cause you to grow a beard. Why is that? I’ll be explaining my theory in the next article, “HCG is a Hairy Hormone”. Visit metabolism.com for more on this, in the very near future.